Overexpression of Candida albicans CDR1 , CDR2 , or MDR1 Does Not Produce Significant Changes in Echinocandin Susceptibility
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چکیده
منابع مشابه
Overexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility.
The micafungin and caspofungin susceptibilities of Candida albicans laboratory and clinical isolates and of Saccharomyces cerevisiae strains stably hyperexpressing fungal ATP-binding cassette (ABC) or major facilitator superfamily (MFS) transporters involved in azole resistance were determined using three separate methods. Yeast strains hyperexpressing individual alleles of ABC transporters or ...
متن کاملUsing PCR to Compare the Expression of CDR1, CDR2, and MDR1 in Candida Albicans Isolates Resistant and Susceptible to Fluconazole
Abstract Background and objectives: More Candida albicans strains are reported resistant to fluconazole in patients with AIDS, cancer and organ recipients. Fluconazole resistance can be attributed to changes in pathways of sterol biosynthesis, mutation in or overexpression of ERG11 and the expression of CDR1, CDR2, and MDR1. This study aimed to compare the ex...
متن کاملRegulated overexpression of CDR1 in Candida albicans confers multidrug resistance.
OBJECTIVES Information on the function of Candida albicans ATP-binding cassette (ABC) membrane transporter Cdr1p has come from studying the effect of gene inactivation in C. albicans and from heterologous Cdr1p expression in the yeast Saccharomyces cerevisiae. These approaches, however, give only an indirect indication of Cdr1p function in C. albicans itself. The objective of this study was to ...
متن کاملusing pcr to compare the expression of cdr1, cdr2, and mdr1 in candida albicans isolates resistant and susceptible to fluconazole
abstract background and objectives: more candida albicans strains are reported resistant to fluconazole in patients with aids, cancer and organ recipients. fluconazole resistance can be attributed to changes in pathways of sterol biosynthesis, mutation in or overexpression of erg11 and the expression of cdr1, cdr2, and mdr1. this study aimed to compare the expression of cdr1, cdr2, and md...
متن کاملTranscriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans.
Many azole-resistant (AR) clinical isolates of Candida albicans display increased expression of the drug transporters CDR1 and CDR2. In this study, we evaluate the molecular mechanisms that contribute to the maintenance of constitutively high CDR1 transcript levels in two matched pairs of azole-susceptible (AS) and AR clinical isolates of C. albicans. To address this, we use reporter constructs...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2006
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.50.4.1148-1155.2006